Speaking to the media in the 'pearl city', the superstar said, "There is no power greater than people power. They should not even think about re-opening the Sterlite plant. If they do, they are not humans."
Rajini, who plays a man hailing from Thoothukudi in his upcoming film Kaala, visited the people injured during the Sterlite protest at the government hospital.
He also offered condolences to the family of those killed during the incident.
An ocean of fans gathered along the streets to see the actor, who stood up and waved back to them from the sunroof of his car which was making its way to the hospital.
Rajinikanth announced a compensation of Rs two lakh to those who were killed last week and Rs 10,000 to 48 victims who were injured in the unfortunate incident.
Speaking to the gathering he said, "This is the first time I am coming to Thoothukudi. But, I feel sorry that I am coming here on the backdrop of such a sad incident."
He added: "My visit to the Thoothukudi district is a goodwill gesture. As an actor if they (people injured in protests) see me, it might bring them happiness."
Expressing that he has no belief in the inquiry commission set up by the government, Rajini said, "Higher officials who were involved in police firing should be punished. Intelligence failure was the main reason behind the violence."
Slamming both the AIADMK and the DMK, he said, "This is all politics. They will keep blaming each other.'
He said: "Sila visha kirumigal (anti-social elements) are instigating violence and they need to be weeded out. People should be wary of them."
'UPPITTA' TAMIZH MANNAI...
Twitter too went into a frenzy as #thalaivarinthoothukudi went to number one in trendsmapindia only to be replaced by #modiinindonesia half an hour later.